By Walter A. Korfmacher
The first variation of this now vintage paintings helped to set up mass spectrometry because the most effective software for drug metabolism stories. thoroughly rewritten from begin to end, Using Mass Spectrometry for Drug Metabolism experiences, moment version brings medicinal chemists and mass spectrometry execs on top of things with the speedy advances within the box, the emergence of state-of-the-art methods, and how one can meet progressively expanding seller calls for. Written through foreign scientists who're specialists of their respective disciplines, this cutting-edge reference successfully encapsulates present mass spectrometry most sensible practices.
The stand-alone chapters conceal numerous themes – from metabolite identity to quick chromatography with UPLC – and in a mode that's comprehensible to specialists and box newbies alike. the second one variation of this bestseller comprises insurance of recent instrumentation and software program in addition to a wealth of up to date details at the newest findings surrounding biomarkers and metabolomics and new chapters on either UPLC and DESI/DART.
With greater than a hundred and eighty illustrations and an eight-page colour insert, this important reference explores a number of sleek mass spectrometry thoughts and techniques. It contains a superb evaluation of the complete drug discovery procedure plus the most recent advancements on how mass spectrometry is used to aid this exercise.
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Technol. Biomed. , 833(2), 219, 2006. 60. Du, L. , Improved partition equilibrium model for predicting analyte response in electrospray ionization mass spectrometry, J. , 44(2), 222, 2009. 61. Du, L. , Reducing glycerophosphocholine lipid matrix interference effects in biological fluid assays by using high-turbulence liquid chromatography, Rapid Commun. , 22(21), 3362, 2008. 62. X. , Minimization of ion suppression in LC-MS/MS analysis through the application of strong cation exchange solid-phase extraction (SCX-SPE), J.
For more on UPLC, see Chapter 8. Xu et al.  also discussed the potential for high-field asymmetric waveform ion mobility spectrometry (FAIMS) to provide additional specificity to HPLC–MS/MS assays. FAIMS is added to an HPLC–MS/MS system by inserting it in between the atmospheric pressure ionization (API) source and the entrance to the MS system. The transmission of ions through the FAIMS device is controlled (in part) by the compensation voltage that is applied. The compensation voltage can be adjusted such that the mobility of ions through the FAIMS can be very selective.
REFERENCES 1. MacCoss, M. , Organic chemistry in drug discovery, Science, 303(5665), 1810, 2004. 2. G. , The role of the medicinal chemist in drug discovery—then and now, Nat. Rev. , 3(10), 853, 2004. 3. , Managing the drug discovery/development interface, Drug Discov. Today, 2(10), 436, 1997. 4. , The evolving role of drug metabolism in drug discovery and development, Pharm. , 24(5), 842, 2007. 5. N. , Role of drug metabolism in drug discovery and development, Med. Res. , 21(5), 397, 2001. 6. , Lead optimization strategies as part of a drug metabolism environment, Curr.