Handbook of Combinatorial Chemistry: Drugs, Catalysts, by K. C. Nicolaou, Rudolf Hanko, Wolfgang Hartwig

By K. C. Nicolaou, Rudolf Hanko, Wolfgang Hartwig

In the end, the mechanism-based and application-oriented guide of combinatorial chemistry.Since its very starting, examine during this box has endured to enhance at a swift price. more and more based tools are being invented and an excellent wider variety of attainable functions remains to be being chanced on, such that combinatorial chemistry is now a vital part of commercial and educational research.The high-class editorial group - okay. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer - make sure finished assurance and firstclass contributions. This two-volume paintings bargains with man made chemistry in all its types, purposes from lifestyles sciences, chemistry andmaterial sciences, all there's to understand approximately compound library layout and synthesis, and, after all, the final fundamentals - making it an necessary reference for artificial, natural and medicinal chemists, chemical biologists in addition to fabric scientists.

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In the pharmaceutical world, the importance of process chemistry lies at the two extremes. For single compound synthesis in a medicinal chemistry laboratory, a good process may be on the ‘‘nice to have’’ list, but as long as the synthesis scheme affords some of the desired compounds, intermediate and endstage purifications will overcome deficiencies in the process. For bulk pharmaceutical production, the process is everything: it must be extremely efficient, fully validated, and conform to regulated manufacturing practices.

W. Czarnik, S. H. DeWitt, A Chemistry, Academic Press, San Diego, 1996. 2 G. Jung, Combinatorial Peptide and Nonpeptide Libraries: A Handbook, VCH, Weinheim, 1996. 3 I. M. Chaiken, K. D. Janada, Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery, ACS, Washington, DC, 1996. Practical Guide to Combinatorial Chemistry, American Chemical Society, Washington, DC, 1997. 5 G. B. Fields, Solid-Phase Peptide Synthesis, Academic Press, San Diego, 1997. 6 B. A. Bunin, The Combinatorial Index, Academic Press, San Diego, 1998.

Weinberg Symyx Technologies Inc. 3100 Central Expressway Santa Clara CA 95051 USA Jean-Franc¸ois Stumbe´ Freiburger Materialforschungszentrum und Institut fu¨r Makromolekulare Chemie Albert-Ludwigs-Universita¨t Freiburg Stefan-Meier-Str. 21 D-79104 Freiburg Germany T. Weskamp Symyx Technologies Inc. 3100 Central Expressway Santa Clara CA 95051 USA Sean V. Taylor Laboratorium fu¨r Organische Chemie ETH Ho¨nggerberg-HCI CH-8093 Zu¨rich Switzerland Arounarith Tuch Bayer AG Central Research ZF-LSc-KC D-51368 Leverkusen Germany Tetsuo Uno Genomics Institute of the Novartis Research Foundation 3115 Merryfield Row Suite 200 San Diego CA 92121 USA Yasuhiro Uozumi Laboratory of Complex Catalysis Institute for Molecular Science Nishigonaka 38 Myodaiji Okazaki 444-8585 Japan Chi-Huey Wong Department of Chemistry and Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 N.

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