Free Radicals, Nitric Oxide and Inflammation: Molecular, by Nitric Oxide, and Inflammation: Molecular, Biochemical, and

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R. Vane, Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin, Pharmacol. , 30 (1979) 293-331. S. Yamamoto, Enzymes in the arachidonic acid cascade. ), Prostaglandins and Related Substances. , 1983, pp. 95-126. T. M. Rapoport and H. 59 (1986) 192-272. Z. Lankin, H. Kuhn, C. Hiebsch, T. M. K. T. Acta 44 (1985) 655-664. B. B. N. Z. Nauk 377 (2001) 402-405 (English translation in Doklady Biochemistry). E. F. L. Willson, Direct observation of a free radical interaction between vitamin E and vitamin C, Nature 278 (1979) 737-738.

The antioxidant effects of the flavonoids present in diverse plant foods represent one mechanism that could contribute to the cardiovascular protective effects of plant-rich diets. Cocoa and chocolate can represent particularly rich sources of dietary flavonoids, cocoa containing up to 10% flavonoids by weight. Flavanols and procyanidins (oligomers of flavanols) isolated from cocoa display strong antioxidant properties in a number of in vitro systems. In acute feeding trials with healthy adult subjects, the consumption of flavanol-rich cocoa and chocolate was associated with increases in plasma antioxidant capacity, reduction in the rate of LDL-oxidation, and reduction in platelet reactivity.

A. 86. 1989 9697-9701. Nair. J. In Singer, B. and Bartsch, H. ). Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis. I ARC Scientific Publication No. 150, 1999. pp. 55-61. Singer. B. and Bartsch, H. Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis. IARC Scientific Publications. 1999 Dizdaroglu. M. Oxidative damage to DNA in mammalian chromatin Mutat Res. 275. 1992. 331-342. Free Radicals, Nitric Oxide and Inflammation: Molecular, Biochemical, and Clinical Aspects A. Tomasi et al. ), Madrid, Spain Abstract: Cyclosporine A (CsA) therapy is associated with side effects related to oxidative stress.

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