[Article] Robust modeling in screening studies estimation of by Shen Y.

By Shen Y.

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All three displayed rising 24 hour urinary oestrogen concentrations during the follicular phase, and rising urinary pregnanediol concentrations in the luteal phase. LH levels were measured several times daily and the data clearly reveals the exact time of onset of the LH surge. Jones began in Norfolk using gonadotrophins for ovarian stimulation. Jean Cohen began in Paris, Wilfred Feichtinger and Peter Kemeter in Vienna, Klaus Diedrich and Hans van der Venn in Bonn, Lars Hamberger and Matts Wikland in Sweden, and Andre van Steirteghem and Paul Devroey in Brussels.

Am J Obstet Gycecol (1974); 118:985–9. 32 Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet 1976; 1:880–2. Textbook of assisted reproductive techniques 24 33 Edwards RG, Steptoe PC, Purdy JM. Clinical aspects of pregnancies established with cleaving embryos grown in vivo. Br J Obstet Gynecol (1980); 87:757–68. 34 Trounson AO, Leeton JF, Wood C, et al. Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle.

Endless human studies were now opening. It was easy now to calculate the timing of the final stages of maturation as ending at about 36 hours, which would be the moment for insemination. All these gaps in knowledge had to be filled, but now we were on the way to human IVF. And at this wonderful moment, John Paul, an outstanding cell biologist, invited me to join him and Robin Cole in Glasgow University to study differentiation in early mammalian embryos. This was exciting, to work in biochemistry with a leading cell biologist.

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